Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma.

نویسندگان

  • Kelly J Brunst
  • Yuet-Kin Leung
  • Patrick H Ryan
  • Gurjit K Khurana Hershey
  • Linda Levin
  • Hong Ji
  • Grace K Lemasters
  • Shuk-Mei Ho
چکیده

Kelly J. Brunst, Ph.D.1,2,†, Yuet-Kin Leung, Ph.D.2,3, Patrick H. Ryan, Ph.D.1,2,4, Gurjit K. Khurana Hershey, M.D., Ph.D.5, Linda Levin, Ph.D.1,2, Hong Ji, Ph.D.5, Grace K. LeMasters, Ph.D.1, and Shuk-Mei Ho, Ph.D.2,3,6 1Division of Epidemiology and Biostatistics, University of Cincinnati College of Medicine, 3223 Eden Avenue, Kettering Building, Cincinnati, OH 2Center for Environmental Genetics, University of Cincinnati College of Medicine, 3223 Eden Avenue, Kettering Building, Cincinnati, OH 3Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati College of Medicine, 3223 Eden Avenue, Kettering Building, Cincinnati, OH 4Division of Biostatistics and Epidemiology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, MLC 7037, Cincinnati, OH 5Division of Asthma Research, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, MLC 7037, Cincinnati, OH 6Cincinnati Veteran Affairs Medical Center, Merit Scholar, 3200 Vine Street, Cincinnati, OH

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FOXP3 and TGF-β Gene Polymorphisms in Allergic Rhinitis

Background: Regulatory CD4+T (Treg) cells are effective in maintaining immune tolerance. Objective: To investigate single nucleotide polymorphisms (SNPs) of Transforming Growth Factor β-1 (TGF-β1) and Forkhead Box Protein 3 (FOXP3) genes in Iranian patients with allergic rhinitis (AR). Methods: Variations at codons 10 and 25 of TGF-β1 and FOXP3 at positions -3279 A>C and -924 A>G were evaluated...

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عنوان ژورنال:
  • The Journal of allergy and clinical immunology

دوره 131 2  شماره 

صفحات  -

تاریخ انتشار 2013